- J. B. Fu, Y. Zhang, Y. X. Wang, H. N. Zhang, J. Liu, J. Tang, Q. X. Yang, H. C. Sun, W. Q. Qiu, Y. H. Ma, Z. R. Li, M. Y. Zheng, F. Zhu*. Optimization of metabolomic data processing using NOREVA. Nature Protocols (impact factor of the publication year: 13.491, 生物一区 TOP 期刊). 17(1): 129-151 (2022). PMID: 34952956.
Featured Article:
Media Coverage & News Report:
- Beijing Academy of AI. Dec 31th, 2021.
- Chowdera.com. Dec 31th, 2021.
- CPS@ZJU. Dec 30th, 2021.
- Chinese ZhiHu. Dec 31th, 2021.
- DrugAI. Dec 31th, 2021.
- eBiotrade. Jan 1th, 2022.
- ECHEMI.com. Jan 27th, 2022.
- Gene Online. Jan 1th, 2022.
- India Education Diary. Jan 28th, 2022.
- Mirage News. Jan 27th, 2022.
- Neurons AI. Jan 27th, 2022.
- NSF@Zhejiang. Jan 24th, 2022.
- Tencent Cloud. Jan 1th, 2022.
- ZJU Newsroom. Jan 26th, 2022.
- Zhejiang University. Dec 30th, 2021.
- Y. X. Wang, S. Zhang, F. C. Li, Y. Zhou, Y. Zhang, Z. W. Wang, R. Y. Zhang, J. Zhu, Y. X. Ren, Y. Tan, C. Qin, Y. H. Li, X. X. Li, Y. Z. Chen*, F. Zhu*. Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics. Nucleic Acids Research (impact factor of the publication year: 11.501, 生物一区 TOP 期刊). 48(D1): 1031-1041 (2020). PMID: 31691823.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.14% in 2022.
- The Percentile in Subject Area shown in InCites™ was 0.15% in 2021.
Media Coverage & News Report:
- Q. X. Yang, Y. X. Wang, Y. Zhang, F. C. Li, W. Q. Xia, Y. Zhou, Y. Q. Qiu, H. L. Li, F. Zhu*. NOREVA: enhanced normalization and evaluation of time-course and multi-class metabolomic data. Nucleic Acids Research (impact factor of the publication year: 11.501, 生物一区 TOP 期刊). 48(W1): 436-448 (2020). PMID: 32324219.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 2.17% in 2022.
Media Coverage & News Report:
- J. Y. Yin, W. Sun, F. C. Li, J. J. Hong, X. X. Li, Y. Zhou, Y. J. Lu, M. Z. Liu, X. Zhang, N. Chen, X. P. Jin, J. Xue, S. Zeng*, L. S. Yu*, F. Zhu*. VARIDT 1.0: variability of drug transporter database. Nucleic Acids Research (impact factor of the publication year: 11.501, 生物一区 TOP 期刊). 48(D1): 1042-1050 (2020). PMID: 31495872.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.98% in 2022.
- The Percentile in Subject Area shown in InCites™ was 0.33% in 2021.
Media Coverage & News Report:
- Y. H. Li, C. Y. Yu, X. X. Li, P. Zhang, J. Tang, Q. X. Yang, T. T. Fu, X. Y. Zhang, X. J. Cui, G. Tu, Y. Zhang, S. Li, F. Y. Yang, Q. Sun, C. Qin, X. Zeng, Z. Chen, Y. Z. Chen*, F. Zhu*. Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics. Nucleic Acids Research (impact factor of the publication year: 11.561, 生物一区 TOP 期刊). 46(D1): 1121-1127 (2018). PMID: 29140520.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.21% in 2022.
- The Percentile in Subject Area shown in InCites™ was 0.15% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.14% in 2020.
- The Percentile in Subject Area shown in InCites™ was 0.16% in 2019.
Highlights by Experts in Subject Area:
- Introduced by OMICTOOLS as "useful for facilitating patient focused research, discovery and clinical investigations of the targeted therapeutics".
- B. Li, J. Tang, Q. X. Yang, S. Li, X. J. Cui, Y. H. Li, Y. Z. Chen, W. W. Xue, X. F. Li, F. Zhu*. NOREVA: normalization and evaluation of MS-based metabolomics data. Nucleic Acids Research (impact factor of the publication year: 10.162, 生物一区 TOP 期刊). 45(W1): 162-170 (2017). PMID: 28525573.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.84% in 2022.
- The Percentile in Subject Area shown in InCites™ was 0.71% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.75% in 2020.
- The Percentile in Subject Area shown in InCites™ was 1.27% in 2019.
- The Percentile in Subject Area shown in InCites™ was 2.98% in 2018.
Highlights by Experts in Subject Area:
- Introduced by OMICTOOLS as "provided valuable guidance to the selection of suitable algorithm in metabolomics".
- Discussed in StackExchange as "works fine" and "corrections for batches without QC options".
- T. T. Fu, F. C. Li, Y. Zhang, J. Y. Yin, W. Q. Qiu, X. D. Li, X. G. Liu, W. W. Xin, C. Z. Wang, L. S. Yu, J. Q. Gao, Q. C. Zheng*, S. Zeng*, F. Zhu*. VARIDT 2.0: structural variability of drug transporter. Nucleic Acids Research (impact factor of the publication year: 16.971, 生物一区 TOP 期刊). 50(D1): 1417-1431 (2022). PMID: 34747471.
Media Coverage & News Report:
- X. N. Wang, F. C. Li, W. Q. Qiu, B. B. Xu, Y. L. Li, X. C. Lian, H. Y. Yu, Z. Zhang, J. X. Wang, Z. R. Li, W. W. Xue*, F. Zhu*. SYNBIP: synthetic binding proteins for research, diagnosis and therapy. Nucleic Acids Research (impact factor of the publication year: 16.971, 生物一区 TOP 期刊). 50(D1): 560-570 (2022). PMID: 34664670.
Media Coverage & News Report:
- J. Y. Yin, F. C. Li, Y. Zhou, M. J. Mou, Y. J. Lu, K. L. Chen, J. Xue, Y. C. Luo, J. B. Fu, X. He, J. Q. Gao, S. Zeng*, L. S. Yu*, F. Zhu*. INTEDE: interactome of drug-metabolizing enzymes. Nucleic Acids Research (impact factor of the publication year: 16.971, 生物一区 TOP 期刊). 49(D1): 1233-1243 (2021). PMID: 33045737.
Media Coverage & News Report:
- J. Tang, X. L. Wu, M. J. Mou, C. Wang, L. D. Wang, F. C. Li, M. Y. Guo, J. Y. Yin, W. Q. Xie, X. N. Wang, Y. X. Wang, Y. B. Ding*, W. W. Xue*, F. Zhu*. GIMICA: host genetic and immune factors shaping human microbiota. Nucleic Acids Research (impact factor of the publication year: 16.971, 生物一区 TOP 期刊). 49(D1): 715-722 (2021). PMID: 33045729.
Media Coverage & News Report:
- F. Zhu, Z. Shi, C. Qin, L. Tao, X. Liu, F. Xu, L. Zhang, Y. Song, X. H. Liu, J. X. Zhang, B. C. Han, P. Zhang, Y. Z. Chen*. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Research (impact factor of the publication year: 8.026, 生物一区 TOP 期刊). 40(D1): 1128-1136 (2012). PMID: 21948793.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.77% in 2022.
- The Percentile in Subject Area shown in InCites™ was 0.69% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.66% in 2020.
- The Percentile in Subject Area shown in InCites™ was 0.60% in 2019.
- The Percentile in Subject Area shown in InCites™ was 0.62% in 2018.
- The Percentile in Subject Area shown in InCites™ was 0.31% in 2017.
Highlights by Experts in Subject Area:
- "FACULTYof1000" as "the top 2% of published articles in biology and medicine" and "a most useful resource for scientists and companies working on drug discovery and validation, drug lead discovery and optimization, and the development of multi-target drugs and drug combinations".
- Prof. Chris Southan in his blog as "Therapeutic Target Database in PubChem".
- F. Zhu, B. C. Han, P. Kumar, X. H. Liu, X. H. Ma, X. N. Wei, L. Huang, Y. F. Guo, L. Y. Han, C. J. Zheng, Y. Z. Chen*. Update of TTD: therapeutic target database. Nucleic Acids Research (impact factor of the publication year: 7.479, 生物一区 TOP 期刊). 38(D1): 787-791 (2010). PMID: 19933260.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 2.95% in 2017.
- F. Zhu, C. Qin, L. Tao, X. Liu, Z. Shi, X. H. Ma, J. Jia, Y. Tan, C. Cui, J. S. Lin, C. Y. Tan, Y. Y. Jiang*, Y. Z. Chen*. Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proceedings of the National Academy of Sciences of the United States of America (impact factor of the publication year: 9.432, 综合性一区 TOP 期刊). 108(31): 12943-12948 (2011). PMID: 21768386.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.97% in 2022.
- The Percentile in Subject Area shown in InCites™ was 0.98% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.93% in 2020.
- The Percentile in Subject Area shown in InCites™ was 0.94% in 2019.
- The Percentile in Subject Area shown in InCites™ was 1.16% in 2018.
- The Percentile in Subject Area shown in InCites™ was 1.91% in 2017.
Highlights by Experts in Subject Area:
Media Coverage & News Report:
- NEWS MEDICAL. Sep 8th, 2011.
- Medical News Today (MNT). Sep 7th, 2011.
- mediLexicon.com. Sep 7th, 2011.
- BrightSurf.com. Sep 7th, 2011.
- SCIENCE CODEX. Sep 6th, 2011.
- Sciencenewsline biology. Sep 6th, 2011.
- Medical Xpress. Sep 6th, 2011.
- First Science News. Sep 6th, 2011.
- Lab spaces.net. Sep 6th, 2011.
- Eurek Alert. Sep 6th, 2011.
- eBioNews. Sep 1st, 2011.
- Science Daily. Aug 31st, 2011.
- Health Canal.com. Aug 31st, 2011.
- News Ecology. Aug 31st, 2011.
- Y. H. Li, X. X. Li, J. J. Hong, Y. X. Wang, J. B. Fu, H. Yang, C. Y. Yu, F. C. Li, J. Hu, W. W. Xue, Y. Y. Jiang, Y. Z. Chen*, F. Zhu*. Clinical trials, progression-speed differentiating features, and swiftness rule of the innovative targets of first-in-class drugs. Briefings in Bioinformatics (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(2): 649-662 (2020). PMID: 30689717.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.49% in 2022.
- The Percentile in Subject Area shown in InCites™ was 0.09% in 2021.
- J. Tang, J. B. Fu, Y. X. Wang, B. Li, Y. H. Li, Q. X. Yang, X. J. Cui, J. J. Hong, X. F. Li, Y. Z. Chen, W. W. Xue, F. Zhu*. ANPELA: analysis and performance-assessment of the label-free quantification workflow for metaproteomic studies. Briefings in Bioinformatics (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(2): 621-636 (2020). PMID: 30649171.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.20% in 2022.
- The Percentile in Subject Area shown in InCites™ was 0.05% in 2021.
- Q. X. Yang, B. Li, J. Tang, X. J. Cui, Y. X. Wang, X. F. Li, J. Hu, Y. Z. Chen, W. W. Xue, Y. Lou, Y. Q. Qiu*, F. Zhu*. Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data. Briefings in Bioinformatics (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(3): 1058-1068 (2020). PMID: 31157371.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.61% in 2022.
- The Percentile in Subject Area shown in InCites™ was 0.19% in 2021.
- J. J. Hong, Y. C. Luo, M. J. Mou, J. B. Fu, Y. Zhang, W. W. Xue, T. Xie, L. Tao*, Y. Lou*, F. Zhu*. Convolutional neural network-based annotation of bacterial type IV secretion system effectors with enhanced accuracy and reduced false discovery. Briefings in Bioinformatics (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(5): 1825-1836 (2020). PMID: 31860715.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 2.22% in 2022.
- Z. J. Han, W. W. Xue, L. Tao, Y. Lou, Y. Q. Qiu*, F. Zhu*. Genome-wide identification and analysis of the eQTL lncRNAs in multiple sclerosis based on RNA-seq data. Briefings in Bioinformatics (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(3): 1023-1037 (2020). PMID: 31323688.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 2.22% in 2022.
- J. J. Hong, Y. C. Luo, Y. Zhang, J. B. Ying, W. W. Xue, T. Xie, L. Tao*, F. Zhu*. Protein functional annotation of simultaneously improved stability, accuracy and false discovery rate achieved by a sequence-based deep learning. Briefings in Bioinformatics (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(4): 1437-1447 (2020). PMID: 31504150.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 1.54% in 2022.
- F. C. Li, Y. Zhou, Y. Zhang, J. Y. Yin, Y. Q. Qiu, J. Q. Gao, F. Zhu*. POSREG: proteomic signature discovered by simultaneously optimizing its reproducibility and generalizability. Briefings in Bioinformatics (impact factor of the publication year: 11.622, 生物一区 TOP 期刊). 23(2): bbac040 (2022). PMID: 35183059.
- S. Zhang, K. Amahong, C. Y. Zhang, F. C. Li, J. Q. Gao, Y. Q. Qiu*, F. Zhu*. RNA-RNA interactions between SARS-CoV-2 and host benefit viral development and evolution during COVID-19 infection. Briefings in Bioinformatics (impact factor of the publication year: 11.622, 生物一区 TOP 期刊). 23(1): bbab397 (2022). PMID: 34585235.
- S. Zhang, Y. Zhou, Y. N. Wang, Z. W. Wang, Q. T. Xiao, Y. Zhang, Y. Lou, Y. Q. Qiu*, F. Zhu*. The mechanistic, diagnostic and therapeutic novel nucleic acids for hepatocellular carcinoma emerging in past score years. Briefings in Bioinformatics (impact factor of the publication year: 11.622, 生物一区 TOP 期刊). 22(2): 1860-1883 (2021). PMID: 32249290.
- J. B. Fu, Y. Zhang, J. Liu, X. C. Lian, J. Tang, F. Zhu*. Pharmacometabonomics: data processing and statistical analysis. Briefings in Bioinformatics (impact factor of the publication year: 11.622, 生物一区 TOP 期刊). 22(5): bbab138 (2021). PMID: 33866355.
- J. Tang, M. J. Mou, Y. X. Wang, Y. C. Luo, F. Zhu*. MetaFS: performance assessment of biomarker discovery in metaproteomics. Briefings in Bioinformatics (impact factor of the publication year: 11.622, 生物一区 TOP 期刊). 22(3): bbaa105 (2021). PMID: 32510556.
- J. Tang, Y. X. Wang, J. B. Fu, Y. Zhou, Y. C. Luo, Y. Zhang, B. Li, Q. X. Yang, W. W. Xue, Y. Lou, Y. Q. Qiu*, F. Zhu*. A critical assessment of the feature selection methods used for biomarker discovery in current metaproteomic studies. Briefings in Bioinformatics (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(4): 1378-1390 (2020). PMID: 31197323.
- Q. X. Yang, J. J. Hong, Y. Li, W. W. Xue, S. Li*, H. Yang*, F. Zhu*. A novel bioinformatics approach to identify the consistently well-performing normalization strategy for current metabolomic studies. Briefings in Bioinformatics (impact factor of the publication year: 9.101, 生物一区 TOP 期刊). 21(6): 2142-2152 (2020). PMID: 31776543.
- S. Zhang, F. Zhu*. Comment on microRNA mimics or inhibitors as antiviral therapeutic approaches against COVID-19. Drugs (impact factor of the publication year: 9.542, 医学二区 TOP 期刊). 81(14): 1691-1692 (2021). PMID: 34453690.
- Y. X. Wang, F. C. Li, Y, Zhang, Y. Zhou, Y. Tan, Y. Z. Chen*, F. Zhu*. Databases for the targeted COVID-19 therapeutics. British Journal of Pharmacology (impact factor of the publication year: 7.730, 医学二区 TOP 期刊). 177(21): 4999-5001 (2020). PMID: 32845521.
- J. Y. Yin, X. X. Li, F. C. Li, Y. J. Lu, S. Zeng*, F. Zhu*. Identification of the key target profiles underlying the drugs of narrow therapeutic index for treating cancer and cardiovascular disease. Computational and Structural Biotechnology Journal (impact factor of the publication year: 7.271, 生物二区期刊). 19: 2318-2328 (2021). PMID: 33995923.
- J. Tang, Y. X. Wang, Y. C. Luo, J. B. Fu, Y. Zhang, Y. Li, Z. Y. Xiao, Y. Lou, Y. Q. Qiu*, F. Zhu*. Computational advances of tumor marker selection and sample classification in cancer proteomics. Computational and Structural Biotechnology Journal (impact factor of the publication year: 6.018, 生物二区 TOP 期刊). 18: 2012-2025 (2020). PMID: 32802273.
- T. T. Fu, G. Tu, M. Ping, G. X. Zheng, F. Y. Yang, J. Y. Yang, Y. Zhang, X. J. Yao, W. W. Xue*, F. Zhu*. Subtype selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptors. Acta Pharmacologica Sinica (impact factor of the publication year: 6.150, 医学一区 TOP 期刊). 42(8): 1354-1367 (2021). PMID: 33122823.
- J. Tang, J. B. Fu, Y. X. Wang, Y. C. Luo, Q. X. Yang, B. Li, G. Tu, J. J. Hong, X. J. Cui, Y. Z. Chen, L. X. Yao, W. W. Xue, F. Zhu*. Simultaneous improvement in the precision, accuracy and robustness of label-free proteome quantification by optimizing data manipulation chains. Molecular & Cellular Proteomics (impact factor of the publication year: 5.236, 生物二区 TOP 期刊). 18(8): 1683-1699 (2019). PMID: 31097671.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 1.12% in 2022.
- The Percentile in Subject Area shown in InCites™ was 0.81% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.57% in 2020.
- F. C. Li, Y. Zhou, X. Y. Zhang, J. Tang, Q. X. Yang, Y. Zhang, Y. C. Luo, J. Hu*, W. W. Xue, Y. Q. Qiu, Q. J. He, B. Yang, F. Zhu*. SSizer: determining the sample sufficiency for comparative biological study. Journal of Molecular Biology (impact factor of the publication year: 5.067, 生物二区 TOP 期刊). 432(11): 3411-3421 (2020). PMID: 32044343.
- W. Q. Xia, L. Y. Zheng, J. B. Fang, F. C. Li, Y. Zhou, Z. Y. Zeng, B. Zhang, Z. R. Li, H. L. Li*, F. Zhu*. PFmulDL: a novel strategy enabling multi-class and multi-label protein function annotation by integrating diverse deep learning methods. Computers in Biology and Medicine (impact factor of the publication year: 4.589, 工程技术二区期刊). 145: 105465 (2022). PMID: 35366467.
- Y. Zhang, J. B. Ying, J. J. Hong, F. C. Li, T. T. Fu, F. Y. Yang, G. X. Zheng, X. J. Yao, Y. Lou, Y. Q. Qiu, W. W. Xue*, F. Zhu*. How does chirality determine the selective inhibition of histone deacetylase 6? A lesson from Trichostatin A enantiomers based on molecular dynamics. ACS Chemical Neuroscience (impact factor of the publication year: 4.211, 化学二区 TOP 期刊). 10(5): 2467-2480 (2019). PMID: 30784262.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 1.99% in 2022.
- The Percentile in Subject Area shown in InCites™ was 1.19% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.74% in 2020.
Cover Article:
- W. W. Xue, F. Y. Yang, P. P. Wang, G. X. Zheng, Y. Z. Chen, X. J. Yao, F. Zhu*. What contributes to serotonin-norepinephrine reuptake inhibitors' dual-targeting mechanism? The key role of transmembrane domain 6 in human serotonin and norepinephrine transporters revealed by molecular dynamics simulation. ACS Chemical Neuroscience (impact factor of the publication year: 4.211, 化学二区 TOP 期刊). 9(5): 1128-1140 (2018). PMID: 29300091.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 0.18% in 2022.
- The Percentile in Subject Area shown in InCites™ was 0.14% in 2021.
- The Percentile in Subject Area shown in InCites™ was 0.21% in 2020.
- The Percentile in Subject Area shown in InCites™ was 0.29% in 2019.
- P. P. Wang, X. Y. Zhang, T. T. Fu, S. Li, B. Li, W. W. Xue*, X. J. Yao, Y. Z. Chen, F. Zhu*. Differentiating physicochemical properties between addictive and nonaddictive ADHD drugs revealed by molecular dynamics simulation studies. ACS Chemical Neuroscience (impact factor of the publication year: 4.348, 化学二区 TOP 期刊). 8(6): 1416-1428 (2017). PMID: 28557437.
ESI Highly Cited Paper:
- The Percentile in Subject Area shown in InCites™ was 2.17% in 2022.
- The Percentile in Subject Area shown in InCites™ was 1.48% in 2021.
- The Percentile in Subject Area shown in InCites™ was 1.80% in 2020.
- The Percentile in Subject Area shown in InCites™ was 1.32% in 2019.
- F. Y. Yang, G. X. Zheng, T. T. Fu, X. F. Li, G. Tu, Y. H. Li, X. J. Yao, W. W. Xue*, F. Zhu*. Prediction of binding mode and resistance profile for dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase associated ribonuclease H. Physical Chemistry Chemical Physics (impact factor of the publication year: 4.123, 化学二区 TOP 期刊). 20(37): 23873-23884 (2018). PMID: 29947629.
Back Cover Article:
- W. W. Xue, T. T. Fu, S. Z. Deng, F. Y. Yang, J. Y. Yang, F. Zhu*. Molecular mechanism for the allosteric inhibition of the human serotonin transporter by antidepressant escitalopram. ACS Chemical Neuroscience (impact factor of the publication year: 4.418, 医学二区期刊). 13(3): 340-351 (2022). PMID: 35041375.
- F. Zhu, L. Y. Han, C. J. Zheng, B. Xie, M. T. Tammi, S. Y. Yang, Y. Q. Wei, Y. Z. Chen*. What are next generation innovative therapeutic targets? Clues from genetic, structural, physicochemical and system profiles of successful targets. Journal of Pharmacology and Experimental Therapeutics (impact factor of the publication year: 3.867, 医学二区 TOP 期刊). 330(1): 304-315 (2009). PMID: 19357322.
Successful Validation of the Constructed Model:
- Pasireotide targeting Somatostatin receptor 1 was approved by FDA in 2011.
- Fingolimod targeting S1P receptor was approved by FDA in 2010.
Ecallantide targeting Plasma Kallikrein was approved by FDA in 2009.
Cinryze targeting C1 esterase was approved by FDA in 2009.
Icatibant targeting BK-2 receptor was approved by FDA in 2008.
Plerixafor targeting CXCR4 was approved by FDA in 2008.
Q. X. Yang, Y. X. Wang, F. C. Li, S. Zhang, Y. C. Luo, Y. Li, J. Tang, B. Li, Y. Z. Chen, W. W. Xue, F. Zhu*. Identification of the gene signature reflecting schizophrenia's etiology by constructing artificial intelligence-based method of enhanced reproducibility. CNS Neuroscience & Therapeutics (impact factor of the publication year: 3.394, 医学二区期刊). 25(9): 1054-1063 (2019). PMID: 31350824.
Cover Article:
Z. J. Han, W. W. Xue, L. Tao, F. Zhu*. Identification of novel immune-relevant drug target genes for alzheimer's disease by combining ontology inference with network analysis. CNS Neuroscience & Therapeutics (impact factor of the publication year: 3.495, 医学二区期刊). 24(12): 1253-1263 (2018). PMID: 30106219.
Honors and Awards:
- Wiley Top Cited Paper Award (2020).
Cover Article:
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